Peptic Ulcer Drugs Types uses and Side effects
- Peptic ulcer, a lesion or sore develops on the lining of the GI tract, including – the oesophagus, stomach or small intestine.
- Peptic ulcers occur due to an imbalance between the secretion of acid, pepsin, bile and gastric mucosal defence.
- An ulcer found in the stomach is called a gastric ulcer and an ulcer found in the duodenum is called a duodenal ulcer.
- Gastric ulcer cause pain after meals and duodenal ulcer pain relieve after meals.
Peptic ulcer drugs
To reduce gastric acid secretion
- H2 – blockers drugs – H2 – blockers drugs taken empty stomach at night to treat peptic ulcer.
To block the action of the H2 receptor and prevent the action of histamine on parietal cell
To reduce the gastric secretion
Also reduce the pepsin activity
Peptic ulcer healing is faster.
Peptic ulcer Drugs are
- Ranitidine – 150 – 300 mg tablet (Rantac).
- Cimetidine – 200 mg.
- Famotidine – 20 – 40 mg.
- Roxatidine – 75 – 150 mg.
- Duodenal and gastric ulcer
- Gastroesophageal reflux disorder
- Stress ulcer.
Proton pump inhibitors –
The drugs are more potent inhibitors of acid secretion in the stomach. It is a more effective and more usable drug that is taken one hour before the meal.
Proton pump inhibitors Mechanism of action
Proton pump inhibitors drug
Block the H+, K+ ATPase pump
Inhibit the gastric acid secretion.
- Omeprazole – 20 – 40 mg capsule / injection.
- Pantoprazole – 40 mg.
- Esomeprazole – 20 – 40 mg.
- Lansoprazole – 15 – 20 mg.
- Gastric ulcer and duodenal ulcer.
- Gastroesophageal reflux disorder (GERD)
- Stress ulcer
- Zollinger – Elinson syndrome (Z – E syndrome).
- Misoprostol – 200 ug.
- Anticholinergic drugs – It is a selective M1 receptor blocker.
- The drug block the gastric M1 receptors and inhibits the gastric secretion.
- Pirenzepin – 100 – 150 mg.
- Propantheline – 15 – 30 mg.
2. To neutralize the gastric acids
- Antacids – Antacids is a chemical substance which is react with gastric acid and inhibit the gastric contents activities.
- It is an insoluble substance, that useful to relieve pain and treat peptic ulcer.
- Mechanism of action – It neutralizes the gastric acid and inhibit the gastric acid secretion.
- Systemic drug – Sodium bicarbonate drug.
- 1 – 5 gm orally.
- Aluminium hydroxide – up to 1 gm.
- Magnesium hydroxide – 0.5 – 1 gm.
- Calcium carbonate – up to 1.5 gm orally.
- Magnesium carbonate – 250 – 500 gm orally.
- Gastric and duodenal ulcer.
- Indigestion, gastritis, heartburn.
- Peptic ulcer pain and burning.
- Adverse effects
- Constipation, hypermagnesemia, diarrhoea
- Hyperphosphatemia, alkalosis.
3. Anti H – pylori Drugs – Helicobacter pylori is a Gram negative bacteria, and most common cause of peptic ulcer.
- The drug take empty stomach.
- Bismuth subsalicylate
- A lesion or sore develops in the lining of GI tract – Peptic ulcer
- Which peptic ulcer causes pain after meals – Gastric ulcer
- Which drug is useful to neutralize the gastric acid – Antacids
- Most common cause of peptic ulcer – H. Pylori