- Constipation occur when stool becomes hard and difficult to pass.
- Common cause of constipation are – inadequate fluid intake, food habits, immobility, medication and endocrine or metabolic disorders etc.
Constipation drugs Classification
- Purgative (cathartics)
- Laxatives (aperient)
- Laxative drugs cause the mild action and eliminate of soft and formed stool.
- Purgative drugs cause the strong action, resulting in more fluid evacuation.
Bulk forming laxatives drugs
- Dietary fibers – like – fruits, oats, etc.
- Isapghulla – 3 – 12 gm – The drug swell and softens the stool.
The drug irritate GI mucosa
Increase secretion and motility of stool
To promote bowel evacuation
- Bisacodil – 5 mg.
- Sinna (plants leaves)
- Docusate sodium – 100 – 400 mg.
- Liquid paraffin (mineral oil) 15 – 30 ml.
- Lactolose – in children = 5 – 30 ml
- In adult = 5 – 30 ml.
Lactolus retain water in intestinal lumen
Increase bulk of the stool and increase the peristalsis
Evacuation of stool
Constipation drug indication
- Drug-induced constipation
- Bedridden patient
- Immobilized patient (paralysis patient)
- Food and drug poisoning
- Colonoscopy and radioscopy procedure
- Post-operative patient.
Constipation drug Adverse effects
- GI irritation, dehydration
- Rectal burning sensation
- Bloating, cramping, diarrhea
- Thirst, electrolyte imbalance, etc.
Constipation drugs Key Points–
- Antimotility drugs is a – Opioid drug
- Most commonly used antimotility drug – Loperamide
- Common constipation drugs is – Purgative and Laxatives.